Biliary stones are one of the most frequent diseases in abdominal surgery. Their diagnosis and treatment have developed a lot recently. The incidence here is becoming like the west, as life styles are becoming more westernized and the average
life
span
lengthens. Bile compositional change, biliary stasis and biliary infection are known to be the three most important causes of gallstone formation.
We studied the relationship among gallstones, bile and blood component by analysis of those composition and clinical feature. We clinical analyzed 106 cases of operations on the patient with gallstone at the Department of Surgery, Kang Nam St.
Mary's
Hospital, Catholic University from Jan. to Dec. 1994.
@ES The result were as follows;
@EN 1) Positive culture rate in bile was 33.7%. E. Coli was the most frequent bacteria in the bile culture (39.7%), then Klebsiella and Enterobacter in that order of frequency. Ciprobay (ciprofloxacin) was the most sensitive antibiotic in the
culture
sensitivity test, then Gentamycin, Piperacillin.
2) The most common type of gallstone was composed of cholesterol (49.1%), then pigment stone and calcium stone (37.1%, 13.2%) respectively. Cholesterol stones and calcium stones were most frequent in females (73.1%, 57.1%), but pigment stones
were
the
most frequent in males(55.0%). Bile culture rate was higher in the pigment stones (40%) than in cholesterol stones (27.5%). Multiple stones were most frequent in the cholesterol stones (73.1%) but single stone in calcium stone (60.0%).
3) On blood analysis, total cholesterol levels were higher in the pigment stones and the incidence of hypercholesterolemia (greater than 200mg/dl) was higher in cholesterol stone, but these are not significant statistically according to various
stones
(P>0.05). Calcium, phospholipid and triglyceride levels were also not significant.
4) On bile analysis, cholesterol levels were lower level in the cholesterol stones then other stones and bile acid was showed significant lower levels in the cholesterol and the calcium stone than other group (P<0.05), but the ratio of
cholesterol
to
bile acid were revealed higher levels in the cholesterol stone and the calcium stone, without statistical meaning (P>0.05). Calcium levels were the highest in the pigment stones remarkably than other groups(P<0.05). Total bilirubin were higher
levels in
the cholesterol, pigment stone than other groups without statistical differance (P>0.05).
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